منابع مشابه
Studies Ox Cholinesterase*
Recent investigations have provided evidence that the release and removal of acetylcholinc is an intracellular process directly connected with the nerve action potential. The experiments suggest that the ester renders the neuronal surface permeable to all ions and thereby depolarizes the membrane (l-4). This concept is based mainly on studies of the enzyme cholinesterase. Three essential featur...
متن کاملStudies on cholinesterase: 5. The selective inhibition of pseudo-cholinesterase in vivo.
Bruce, H. M. & Callow, R. K. (1934). Biochem. J. 28, 517. Grsholm, A. (1935). Beretn. f. Form0o8lab., 168. Copenhagen. Harrison, D. C. & Mellanby, E. (1939). Biochem. J. 38, 1660. Hoff-Jorgensen, E. (1944). Det. kgl. danske Viden8kabernee Selskabs mat.-fy8. Medd. 21, 7 (in English). Larson, C. E. & Greenberg, D. M. (1938). J. biol. Chem. 123, 199. McCance, R. A. & Widdowson, E. M. (1935). Bioch...
متن کاملStudies on cholinesterase; kinetics of the inhibition of acetylcholine esterase.
Enzyme inhibitors have long been used in the analysis of cellular function for separating different steps in complex chemical reactions and for studying the effect of blocking these reactions in the intact cell. Inhibitors of choline ester-splitting enzymes, especially the alkaloids prostigmine and eserine, have attracted the interest of investigators in view of the physiological rale of acetyl...
متن کاملStructure Based 3D-QSAR Studies on Cholinesterase Inhibitors
Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disorder of the elderly. It is characterized by widespread loss of central cholinergic neuronal function (Butters et al., 1995). The only symptomatic treatment proven to be effective to date is the use of cholinesterase inhibitors (ChEI) to augment surviving cholinergic activity (Giacobini, 2003, Terry & Buccafusco, 2003). Two t...
متن کاملStudies on Cholinesterase Iv. on the Mechanism of Diisopropyl Fluorophosphate Action in Vivo*
There is growing evidence for the assumption that the profound biological effects produced by some compounds in low concentrations may be attributed to an interaction with enzymes. This is true for certain cell constituents as well as for toxic compounds not existing normally in the body. Several vitamins have been found to be prosthetic groups of enzymes and for a number of drugs it could be d...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1944
ISSN: 0306-3283
DOI: 10.1042/bj0380086